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Multifunctional 3D-bioprinted antimicrobial cell-laden hydrogel wound dressing for infected wound healing

Multifunctional 3D-bioprinted antimicrobial cell-laden hydrogel wound dressing for infected wound healing

Referência
2024.00331.BD
Data de Início do Projeto
2025-02-01
Data de Fim do Projeto
2029-08-01
Investigador Principal
Área Científica
Engineering And Technology/Materials Engineering

Resumo

Chronic wounds are commonly colonized by biofilm-forming multidrug-resistant pathogens, which hinder treatment and prolong the inflammatory response, making the development of multifunctional dressings urgent. Usnic acid (UA), a natural lichen metabolite, has antimicrobial, antibiofilm, antioxidant, and anti-inflammatory properties. However, the limited water solubility of UA undermines its clinical application. Therefore, a highly biofunctional lipid nanosystem is proposed to enable the encapsulation of the metabolite thereby contributing to bacterial and biofilm eradication. The nanosystem’s targetability, penetration, and therapeutic effect will be further enhanced by the antimicrobial peptide LI14. To ensure an optimal wound healing process, the proposed multimodal nanotechnology strategy is administered together with adipose-derived stem cells. All these components will be added to cellulose-dextran hydrogel precursors, forming an eco-friendly, biocompatible, and biodegradable bioink for 3D bioprinting, paving the way for the development of a ground-breaking scaffold with synergistic antimicrobial and wound healing activity to locally treat infected chronic skin wounds.

Instituições

Instituições Principais

  • Universidade De Coimbra - Faculdade De Farmácia Da Universidade De Coimbra (FF)

Outras Instituições

  • Universidade Do Porto - Instituto De Ciências Biomédicas Abel Salazar Da Universidade Do Porto (ICBAS)
  • Universidade De Coimbra - Faculdade De Farmácia Da Universidade De Coimbra (FF)
  • Universidade De Coimbra - Faculdade De Ciências E Tecnologia Da Universidade De Coimbra - Centro De Engenharia Mecânica, Materiais E Processos (cemmpre) (CEMMPRE)

Financiamento 0,00 €

Fundação para a Ciência e a Tecnologia (FCT) - Portugal

Não disponível