FCT Digital Services
Activity Funded
Exploring Spiro-ß-lactams as Therapeutic Agents Against RNA Virus-Induced Respiratory Infections
Espiro-ß-lactamas como agentes terapêuticos contra infeções respiratórias causadas por vírus ARN
Details
Reference
2023.16671.ICDT
2023.16671.ICDT
Project Start Date
2025-12-15
2025-12-15
Project End Date
2028-12-14
2028-12-14
Principal Investigator
-
Nuno Eduardo Moura Dos Santos Da Costa Taveira
7111-3383-A926
0000-0003-0176-5585
Scientific Area
Medical and health sciences
Medical and health sciences
Funding Program
Concurso de Projetos de IC&DT em Todos os Domínios Científicos 2023
Concurso de Projetos de IC&DT em Todos os Domínios Científicos 2023
Abstract
Respiratory viruses pose significant health and economic challenges, demanding effective antiviral treatments. Spiro-ß-lactams show potent activity against HIV, SARS-CoV-2 and influenza viruses. These broad spectrum compounds could serve as frontline treatments for novel epidemic viruses. We aim to explore their antiviral activity, identify the mechanisms of action, and test efficacy against influenza A in mice, paving the way for human trials.
Institutions
Main Institutions
- Egas Moniz - Cooperativa de Ensino Superior Crl (EgasMonizCES)
Other Institutions
- Universidade Católica Portuguesa (UCP)
- Universidade de Coimbra (UC)
Funding 248.961,60 €
Fundação para a Ciência e a Tecnologia (FCT) - Portugal
248.961,60 €